"目錄號(hào): HY-13915

Apoptosis-

NSC348884是核磷蛋白抑制劑, 破壞低聚物形成和誘導(dǎo)細(xì)胞凋亡，抑制不同癌細(xì)胞系增殖, IC 50為1.7-4.0 μM。

Apoptosis

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Cisplatin-Adarotene-Epibrassinolide-Elesclomol-Betulinic acid-Myricetin-Apoptosis Activator 2-Betulin-Cholesterol myristate-SMIP004-Taurochenodeoxycholic acid-(E)-[6]-Dehydroparadol-Baohuoside I-Bisdemethoxycurcumin-Columbianadin-

生物活性

Description

NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.Target: nucleophosminin vitro: NSC348884 is a putative nucleophosmin small molecular inhibitor? that disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay.? NSC348884 upregulates p53. NSC348884 induces apoptosis.[1]

References

[1].Qi W, et al. NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancercells. Oncogene. 2008 Jul 10;27(30):4210-20.