Dynamic Pluripotent Stem Cell States and Their Applications - PubMed (nih.gov)

摘要

Embryonic pluripotency can be recapitulated in vitro by a spectrum of pluripotent stem cell states stabilized with different culture conditions. Their distinct spatiotemporal characteristics provide an unprecedented tool for the study of early human development. The newly unveiled ability of some stem cell types for crossing xeno-barriers will facilitate the generation of interspecies chimeric embryos from distant species, including humans. When combined with efficient zygote genome editing technologies, xenogeneic human pluripotent stem cells may also open new frontiers for regenerative medicine applications, including the possibility of generating human organs in animals via interspecies chimeric complementation.
胚胎多能性可以在體外通過(guò)一系列用不同培養(yǎng)條件穩(wěn)定的多能干細(xì)胞狀態(tài)來(lái)概括。它們獨(dú)特的時(shí)空特征為研究早期人類發(fā)展提供了前所未有的工具。一些干細(xì)胞類型新發(fā)現(xiàn)的跨越異種屏障的能力將促進(jìn)從包括人類在內(nèi)的遙遠(yuǎn)物種中產(chǎn)生種間嵌合胚胎。當(dāng)與有效的受精卵基因組編輯技術(shù)相結(jié)合時(shí)，異種人類多能干細(xì)胞也可能為再生醫(yī)學(xué)應(yīng)用開(kāi)辟新的領(lǐng)域，包括通過(guò)種間嵌合互補(bǔ)在動(dòng)物體內(nèi)產(chǎn)生人體器官的可能性。

筆記