"目錄號: HY-14598
Diethylstilbestrol是非甾體雌性激素，可作用于更年期和絕經(jīng)后的紊亂。
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Description
Diethylstilbestrol, a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders.Target: Estrogen Receptor/ERRDiethylstilbestrol (DES), a synthetic estrogen that was used in pregnancy, is a prototype endocrine-disrupting chemical. Although prenatal exposure to DES is known to increase risks of vaginal/cervical adenocarcinoma and adverse reproductive outcomes in women, and urogenital anomalies in men, data on nonreproductive medical conditions are lacking. Comparing persons exposed prenatally to DES with those who were not exposed, the hazard ratios were 1.21 (95% confidence interval = 0.96-1.54) for diabetes, 1.27 (1.00-1.62) for all cardiovascular disease, 1.18 (0.88-1.59) for coronary artery disease, 1.28 (0.88-1.86) for myocardial infarction, 1.12 (1.02-1.22) for high cholesterol, 1.14 (1.02-1.28) for hypertension, 1.24 (0.99-1.54) for osteoporosis, and 1.30 (0.95-1.79) for fractures. The associations did not differ by dose and timing of DES exposure, nor, in the women, by the presence or absence of vaginal epithelial changes (a marker of DES host susceptibility) [1]. The role of prenatal exposure to DES as an environmental risk factor for psychiatric disorders requires more evidence before any conclusions can be drawn [2].
Clinical Trial
Yoon Junghan-Genoss Co., Ltd.-Yonsei University
Coronary Artery Disease-Myocardial Ischemia-Myocardial Infarction
January 1, 2017
Shanghai MicroPort Medical (Group) Co., Ltd.
Coronary Artery Disease
September 2010
Phase 3
Azienda Ospedaliero Universitaria Maggiore della Carita
Coronary Artery Disease
March 2014
Micell Technologies
Coronary Artery Disease
February 2011
Phase 2
Essen Technology (Beijing) Co., Ltd.
Ischemic Heart Disease-Myocardial Ischemia-Coronary Artery Lesions,Primary-Coronary Disease-Acute Coronary Syndrome-Furcation Lesion of Coronary Artery
September 2012
JW Medical Systems Ltd
Coronary Artery Disease-Myocardial Ischemia-Coronary Disease-Heart Diseases-Cardiovascular Diseases-Arteriosclerosis-Arterial Occlusive Diseases-Vascular Diseases
November 2013
Phase 2
Astes
Sleep Apnea, Obstructive
January 1, 2016
University of Washington-Sanofi
Prostate Cancer
December 2002
Phase 2
Leonardo Bolognese, MD-Ospedale San Donato
Myocardial Ischemia
June 2010
Phase 4
CID - Carbostent & Implantable Devices
Stable Angina-Unstable Angina-Documented Silent Ischemia
October 2009
Phase 3
San Giuseppe Moscati Hospital
Acute Myocardial Infarction
October 2003
Phase 2-Phase 3
Medical University of Vienna
Coronary Artery Disease
August 2011
Andres I?iguez Romo, MD, PhD-Hospital de Meixoeiro
Coronary Disease
December 2012
Lepu Medical Technology (Beijing) Co., Ltd.
Coronary Artery Disease
July 2013
Phase 4
Boston Scientific Corporation-Labcoat, Ltd.
Coronary Artery Disease
January 2008
Svelte Medical Systems, Inc.
Acute Coronary Syndrome
September 25, 2017
Fondazione Mediolanum per Attività e Ricerche Cardiovascolari Onlus-Mediolanum Cardio Research
Myocardial Infarction
May 2008
CeloNova BioSciences, Inc.-ClinLogix. LLC
Stable Angina
June 2014
Tryton Medical, Inc.
Coronary Atherosclerosis of Native Coronary Artery-Bifurcation Lesions: de Novo Lesions of the Main and Side Branch of Native Coronary Artery
December 2010
University Hospital Heidelberg
Coronary Artery Disease
January 2015
InspireMD
Myocardial Infarction
June 2011
Phase 4
Deutsches Herzzentrum Muenchen
Coronary Heart Disease
April 2012
Phase 4
InspireMD
ST Segment Elevated Myocardial Infarction
October 2015
Phase 4
Boston Scientific Corporation
Atherosclerosis of Native Arteries of the Extremities
July 2013
Beijing Hospital
Coronary Disease
July 2017
Biotronik, Inc.-Biotronik AG-Baim Institute for Clinical Research-Medstar Health Research Institute
Coronary Artery Disease-Atherosclerosis, Coronary-Myocardial Ischemia-Ischemic Heart Disease-Acute Coronary Syndrome-Angina Pectoris
May 2015
Yonsei University
Coronary Bifurcation Lesions
March 2015
Phase 4
Papworth Hospital NHS Foundation Trust
CHD - Coronary Heart Disease-Angina, Stable-Myocardial Ischemia
February 1, 2017
Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease
July 2014
University Hospital, Basel, Switzerland
Coronary Artery Disease-Coronary Thrombosis
April 2010
Phase 4
Aesculap AG
Coronary Artery Disease
August 2010
Phase 3
InspireMD
ST Elevation Myocardial Infarction
June 2013
Medtronic Vascular
Coronary Artery Disease
June 2015
Biotronik AG
Coronary Artery Disease
August 2011
Biotronik France
Coronary Artery Diseases
November 2014
Xiongjing Jiang-Liaoning Biomedical Materials R&D Center Co., Ltd.-Chinese Academy of Medical Sciences, Fuwai Hospital
Ischemic Stroke-Vertebral Artery Stenosis
May 2014
Phase 2-Phase 3
Xuanwu Hospital, Beijing
Ischemic Stroke
January 2014
Biotronik AG
Coronary Artery Disease
May 2011
Phase 4
Fundacja O?rodek Badań Medycznych
Myocardial Infarction
November 2011
Boston Scientific Corporation-Labcoat, Ltd.
Coronary Artery Disease
July 2007
ZhuHai Cardionovum Medical Device Co., Ltd.-R&G Pharma Studies Co.,Ltd.
Coronary Stenosis
August 2016
China National Center for Cardiovascular Diseases
Coronary Artery Disease
December 2009
Sino Medical Sciences Technology Inc.-Nova Vascular LLC
Coronary Artery Disease
July 2017
Yonsei University
Optic Nerve Sheath
October 2013
Kangbuk Samsung Hospital
Anesthesia
August 2016
Phase 3
Kangbuk Samsung Hospital
Anesthesia
July 2016
Phase 3
Kangbuk Samsung Hospital
Anesthesia, General
February 2016
Phase 3
Kangbuk Samsung Hospital
Orthopedic Disorders
November 2015
Phase 3
