When subsetting one column named JPM from a dataframe df

df
1)
if you'd like to have a Series named JPM, then do
df.loc[:, 'JPM']

Series
Afterwards, you could subset the output Series in 1 dimension, e.g.
df.loc[:, 'JPM'][0] -> an item: -1000.0
2)
if you'd like to have a DataFrame with one column named JPM, then do
df.loc[:, ['JPM']] Note that inner bracket

DataFrame
Afterwards, you could subset the output DataFrame in 2 dimensions, e.g.
df.loc[:, ['JPM']].iloc[0, :] -> a Series: -1000 named '2008-01-02 00:00:00'

Series
df.loc[:, ['JPM']].iloc[0, 0] -> an item: -1000