from base64 import b64encode, b64decode

from Crypto.Hash import SHA
from Crypto.PublicKey import RSA
from Crypto.Signature import PKCS1_v1_5


def private_key_signature(message, privatefile):
    #use private key certificate to signature
    privatekey = RSA.importKey(_read_file(privatefile))
    signer = PKCS1_v1_5.new(privatekey)
    return b64encode(signer.sign(SHA.new(message)))

def public_key_verify(message, sign, publicfile):
    #use public key certificate to verify
    publickey = RSA.importKey(_read_file(publicfile))
    verifier = PKCS1_v1_5.new(publickey)
    return verifier.verify(SHA.new(message), b64decode(sign))

def _read_file(file_path):
    with open(file_path, 'rb') as fp:
        return fp.read()

結(jié)果如下：

In [2]: sign = private_key_signature('123456', 'private.pem')

In [3]: sign
Out[3]: 'Uwa55Oa+ru/QbWBnax7jtjKKNbPHk2Nhe1m8BeS2JmDmd0zHQ0oKq6QJ4A23bG51R/kDhz9J/ipsIPpI7lCWzyM7O91SuSAlnq19XpywOB+uk/4RT/Q8AAndbhPlvP0gYxIkd6BKeWckfjvoBvN0fnM17fHpLo0LJwbYrr6zB6g='

In [6]: result = public_key_verify('123456', sign, 'public.pem')

In [7]: result
Out[7]: True