先前在文章“Correlation of Somatic Mutation and Expression Identifies Genes Important in Human Glioblastoma Progression and Survival”中看到了一個詞“non-silent”，non-silent somatic mutation到底包含哪些類型的突變？-然而在百度或者bing上搜索并未搜索一個確定的結(jié)果

于是我就到各個文章上搜non-silent mutation，沒有搜索到完整的結(jié)果：Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma.提到

• We identified a total of 1,596 non-silent mutations, including 1,312 missenses, 85 nonsenses, 25 splice-site variants and 174 insertions or deletions in those 69 PDPCs

• 在ucsc上搜索GBM的突變數(shù)據(jù)時，突變數(shù)據(jù)描述信息上給出這樣的信息
  a non-silent somatic mutation (nonsense, missense, frame-shif indels, splice site mutations, stop codon readthroughs, change of start codon, inframe indels) was identified in the protein coding region of a gene, or any mutation identified in a non-coding gene.

所以non-silent包含

• nonsense,
• missense,
• frame-shif indels
• splice site mutations,
• stop codon readthroughs
• change of start codon
• inframe indels -from ucsc
• insertions or deletions -from《Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma.》

可能上方列出的non-silent mutation不是最全的，如果你覺的還包含哪些類型的突變，請在評論區(qū)留言，寫出你的看法和參考資料

注：ucsc xena提供了non-silent somatic mutation ，它是gene-level的突變矩陣：行是基因，列是樣本，值為1的是突變。

ucsc xena