Overview

Signaling Profiler is a R based pipeline that integrates transcriptomics, proteomics and phosphoproteomics data among a case and a control to build a signaling network, connecting:

cellular receptor(s);
kinases and phosphatases;
targets of phosphorylation;
transcription factors;
This network provides mechanistics hypoteses about the remodeling of the signal due to your case.

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Citation

If you use SignalingProfiler in your research please cite the original publication.

Massacci, G., Venafra, V., Latini, S. et al. A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients. Leukemia (2022). https://doi.org/10.1038/s41375-022-01785-w