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Neuronal Signaling-

TVP1022???????????????S-??????Rasagiline??????MAO-B???????????????

Monoamine Oxidase

相關(guān)產(chǎn)品

Tranylcypromine hemisulfate-Clorgiline hydrochloride-R-(-)-Deprenyl hydrochloride-Rasagiline mesylate-Pargyline hydrochloride-Safinamide-Iproniazid phosphate-Mofegiline hydrochloride-Rosmarinic acid-Phenelzine sulfate-Lazabemide-Moclobemide-Ro 41-1049 hydrochloride-Minaprine-Modaline sulfate-

生物活性

Description

TVP1022 mesylate is the S-isomer of rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor.

References

[1].Ertracht O, et al. The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion. Br J Pharmacol. 2011 Jun;163(4):755-69.

[2].Berdichevski A, et al. TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements. J Pharmacol Exp Ther. 2010 Feb;332(2):413-20.