多肽介紹
多肽是氨基酸以肽鍵連接在一起形成的化合物，具有多種生物學(xué)功能，例如抗血栓形成、抗高血壓、抗菌、抗病毒、抗癌、抗氧化、免疫調(diào)節(jié)、降膽固醇等，目前已廣泛用于功能分析、抗體研究、疫苗開(kāi)發(fā)及藥物研發(fā)等領(lǐng)域。
MCE 配備強(qiáng)大的技術(shù)人才團(tuán)隊(duì)和國(guó)際先進(jìn)的設(shè)備，提供全方位的高質(zhì)量定制肽服務(wù)，包括快速肽合成、標(biāo)準(zhǔn)化學(xué)肽合成、肽修飾、肽庫(kù)和重組多肽表達(dá)，以滿(mǎn)足生物與藥物發(fā)現(xiàn)研究中不斷增長(zhǎng)的多肽需求。
■可選規(guī)格： 毫克（mg）級(jí)至公斤（kg）級(jí)。
■純度范圍： 粗肽、脫鹽、70% 至 98%。
■廣泛修飾： 可提供酰胺化、乙?；?、甲基化、磷酸化、標(biāo)記及偶聯(lián)等 300+ 種不同 修飾。
■合成技術(shù)： 結(jié)合固相合成及液相合成，微波和連接技術(shù)。
■免費(fèi)咨詢(xún)： 專(zhuān)業(yè)的 MCE 技術(shù)團(tuán)隊(duì)為您解答多肽定制的售前與售后的技術(shù)問(wèn)題。
■N 端修飾
?Ac
?Allyl
?Cholesteryl-
?N-Propargylglycine-
?Fmoc
?Acryl
?Fructose-
?Ad
?CBZ
?Alloc
?Glucose-
?BPS-
?Boc
?Pyr
?Morpholine-4-carbonyl-
?Bz
?D-Pyr
?NTriAc
?Trans-Cinnamoyl
?Bz (5-NH2,2-NO2)
?LA-
?PhAc
?2-Furoyl
?Bz (4-F)
?Mpa-
?Py-Ac
?Methacryl-
?Bz (4-NO2)
?Tos
?N-Amidinoglycine
?BPA-
■C 端修飾
?-pNA
?-OMe
?-ONP
?-OSu
?-NH2
?-OEt
?-AMC
?-NHMe
?-ol
?-OBzl
?-AFC
?-NHEt
■脂肪酸化
?For
?MeOSuc
?5-Hexynoic acid
?F-Lau-
?MeOCO
?Iba
?Heptanedioic acid
?Myr-
?2-Br-Ac
?pentenoic acid
?Oct-
?F-Myr-
?2-Cl-Ac
?pentinoyl
?F-Oct-
?Pentadeconyl-
?2-I-Ac
?Hex-
?Dec-
?Pal-
?OH-Ac
?5-heptenoic acid
?Sebacic acid
?Cys (Pal)
?3-Bromopropionyl
?Trans-3-hexenoyl-
?F-Dec-
?Pam3C-
?But-
?Linoletic-
?Undecyl-
?Ste-
?Suc
?10,12-Pentacosadiynoic acid
?Lau-
?Octanedioic acid
■甲基化
?Lys (Me)
?Arg (Me)
?Tyr (Me)
?Tyr (Et)
?Lys (Me2)
?Arg (Me2)asymmetrical
?Thr (Me)
?D-Tyr (Et)
?Lys (Me3)
?Arg (Me2) symmetrical
?Ser (Me)
■磷酸化
?pSer
?D-pSer
?Di-sites in sequence
?4-sites in sequence
?pTyr
?D-pTyr
?Tri-sites in sequence
?5-sites in sequence
?pThr
?D-pThr
■支肽
?Symmetric 2 Branches
?Symmetric 4 Branches
?Symmetric 8 Branches
?Lys symmetric 2 Branches
?Lys symmetric 4 Branches
?Lys symmetric 8 Branches
?Orn symmetric 2 Branches
?Orn symmetric 4 Branches
?Orn symmetric 8 Branches
?Glu 2 Branches (Pure)
?Glycerol 3 Branches ester
?Thr (Peptide2)
?Ser (Peptide2)
?Lys (Peptide2)
■環(huán)肽
?Mono Disulfide bridge
?Double Disulfide bridge
?Triple Disulfide bridge
?Random Triple Disulfide bridge
?Same Sequence Inter-Disulfide bridge by Cys oxidation
?Different Sequence Inter-Disulfide bridge by Cys oxidation
?Oxidation between Se-Cys
?Amide Cyclic (end)
?Amide Cyclic (side chain) by Lys
?Amide Cyclic (side chain) by Orn
■熒光/染料標(biāo)記
?Biotin-
?FITC-
?Dansyl-
?Lys (Dnp)
?DeThioBiotin
?-ED-FITC
?-EDDansyl
?D-Lys (Dnp)
?-EDBiotin
?-Lys (FITC)-
?-Lys (Dansyl)-
?Dab (Dnp)
?Glu (Biotin-PEG2)
?-Lys (FITC)
?-Lys (Dansyl)
?Dap (Dnp)
?-Lys (Biotin)-
?Lys (Ahx-FITC)
?Dansli-e-Lys
?-EDDnp
?-Lys (Biotin)
?FITC-e-Lys
?Dansyl-Ahx-
?-Lys (LC-Biotin)-
?FITC-Ahx-
?5-FAM-
?-Lys (LC-Biotin)
?5-TAMRA-
?5,6-FAM
?Biotin-e-Lys
?5 (6)-TAMTA-
?6’FAM
?Lys (S-S-Biotin)
?-EDYAMRA
?-ED-5-FAM
?Biotin-Ahx-
?-Lys (TAMRA)-
?-Lys (5-FAM)-
?Orn (Bio)
?-Lys (5-TAMRA)
?Lys (5,6-FAM)
?MCA-
?5-TAMRA-e-Lys
?-Lys (5-FAM)
?-Lys (MCA)-
?5-TAMRA-Acp
?5-FAM-E-Lys
?-Lys (MCA)
?5-FAM-Ahx-
?Lys (MCA)-
■BSA、KLH、OVA 偶聯(lián)
?BSA-Peptide N terminus
?KLH-Peptide N terminus
?OVA-Peptide N terminus
?BSA-Peptide C terminus
?KLH-Peptide C terminus
?OVA-Peptide C terminus
?BSA-Peptide via Cys
?KLH-Peptide via Cys
?OVA-Peptide via Cys
■Phe & Tyr 衍生物
?D-2-Cl-Phe
?D-4-F-Phe
?L-2-Me-Phe
?L-3-I-Tyr
?L-2-Cl-Phe
?L-4-F-Phe
?D-4-Me-Phe
?D-3,5-DiI-Tyr
?D-3-Cl-Phe
?D-4-NO2-Phe
?L-4-Me-Phe
?L-3,5-DiI-Tyr
?L-3-Cl-Phe
?L-4-NO2-Phe
?D-4-NH2-Phe
?D-3-NO2-Tyr
?D-4-Cl-Phe
?D-4-I-Phe
?L-4-NH2-Phe
?L-3-NO2-Tyr
?L-4-Cl-Phe
?L-4-I-Phe
?D-3-Cl-Tyr
?D-3,5-DiNO2-Tyr
?D-3,4-DiCl-Phe
?D-3-CN-Phe
?L-3-Cl-Tyr
?L-3,5-DiNO2-Tyr
?L-3,4-DiCl-Phe
?L-3-CN-Phe
?D-3,5-DiCl-Tyr
?L-3-F-Tyr
?D-4-Br-Phe
?D-4-CN-Phe
?L-3,5-DiCl-Tyr
?L-4-NO2-Phg
?L-4-Br-Phe
?L-4-CN-Phe
?D-3,5-DiBr-Tyr
?D-4-NO2-Phg
?D-3-F-Phe
?D-2-Me-Phe
?L-3,5-DiBr-Tyr
?L-3,5-DiF-Phe
?L-3-F-Phe
?D-3-I-Tyr
■Linker
?Gly
?Ava
?AEA
?GABA
?Beta-Ala
?Ahx
?Ado
?Mini-PEG
?Mini-PEG2
?Mini-PEG3
?PEG4
■樹(shù)脂
?peptide on Wang Resin
?peptide on 2-CTC Resin
?peptide on Rink Amide AM Resin
?peptide on Rink Amide MBHA Resin
■D 型氨基酸
?D-Ala
?D-Lys
?D-Glu
?D-Tyr
?D-Arg
?D-Met
?D-Gln
?D-Thr
?D-Asp
?D-Pro
?D-His
?D-Trp
?D-Asn
?D-Phe
?D-Leu
?D-Val
?D-Cys
?D-Ser
■同型氨基酸
?Har
?HomoCit
?beta-HomoMet
?beta-HomoSer
?D-Har
?D-HomoCit
?beta-HomoPro
?beta-HomoThr
?Hcy
?HomoLeu
?beta-HomoVal
?beta-HomoTrp
?HPh
?HomoPro
?beta-HomoAsp
?beta-HomoTyr
?D-HPh
?D-HomoPro
?beta-HomoAsn
?Azidohomoalanine
?Hse
?beta-HomoIle
?beta-HomoGlu
?beta-HomoAla
?D-Hse
?beta-HomoLeu
?beta-HomoGln
?beta-HomoPhe
■特殊氨基酸
?beta-Asp
?3-Thi
?D-Chg
?Cys (pMeBzl)
?D-beta-Asp
?Aib
?Ac6c
?Cys (pMeOBzl)
?gamma-Glu
?Abu
?Dab
?Oic
?D- gamma-Glu
?D-Abu
?Dap
?Tic
?Cys (Cam)
?Hyp
?Pra
?D-Tic
?D-Cys (Cam)
?Phg
?D-Pra
?Cys (Bzl)
?Cys (Acm)
?D-Phg
?Allo-Thr
?Epsilon-Lys
?Cys (tBu)
?Nva
?D-Allo-Thr
?D-Epsilon-Lys
?Cys (StBu)
?D-Nva
?Gly (allyl)
?5-ASA
?Met (O)
?Nle
?D-Gly (allyl)
?Bpa
?D-Met (O)
?D-Nle
?Cys (Pyrene-maleimide)
?Pip
?Cys (SNO)
?Cit
?D-1-Nal
?Nip
?Met (O)2
?D-Cit
?L-1-Nal
?2-Aze
?D-Met (O)2
?Orn
?D-2-Nal
?3-Aze
?Lys (Ac)
?D-Orn
?L-2-Nal
?[Psi (CH2NH)]
?Ac-Lys
?Pen
?D-2-Pal
?[CS-NH]
?Lys (Dde)
?D-Pen
?L-2-Pal
?Se-Met
?Tle
?Cpg
?D-3-Pal
?Se-Cys
?Ser (Octanoic acid)
?Cha
?L-3-pal
?DOPA
?Ser (Lipoic acid)
?D-Cha
?D-4-Pal
?isoGln
?D-Ser (Octanoic acid)
?Chg
?L-4-Pal
?D-isoGln
?Arg (Boc2)
?Asp-OMe
?D-Glu (OtBu)
?Lys (Z)
?Arg (NO2)
?Asp-OtBu
?Gln (Trt)
?Ser (Bzl)
?Arg (Z2)
?Asn (Trt)
?His (Boc)
?Ser (Trt)
?Arg (pbf)
?Cys (MMt)
?His (Trt)
?Ser (tBu)
?D-Arg (pdf)
?Cys (Trt)
?Tyr (propargyl)
?Tyr (tBu)
?Asp (Oall)
?D-Cys (Trt)
?Lys (Boc)
?Asp (OBn)
?Glu (Oall)
?Lys (DMT)
?D-Tyr (tBu)
?Asp (OBzl)
?Glu (OBzl)
?Lys (Fomc)
?Thr (tBu)
?Asp (OMe)
?Glu (OMe)
?Lys (Mtt)
?Trp (Boc)
?Asp (OtBu)
?Glu (OtBu)
?Lys (Trt)
?Trp (Farnesyl)
