cell maker
cancer cells:?EPCAM, CD24, SOX4, KRT18
T cells: CD2, CD3D, TRAC, TRBC2
? ? ?Treg:?Foxp3, CD25, CD4
B cells: CD79A, CD79B, MS4A1
myeloid cells: LYZ, MNDA, C1QA, VCAN, APOE
fibroblasts: COL1A1, COL1A2, LUM, DCN
CAFs:?COL1A1, COL1A2, POSTN, PDGFRA
mural cells: RGS5, MYH11, PDGFRB, NOTCH3
endothelial cells: PECAM1, ENG, PLVAP, CDH5
microglial cells: P2RY12, CX3CR1
oligodendrocytes: OLIG1, OLIG2, MBP, MOG, MAG
other cells: ALB, APOB, HP
ref.:?The Single-Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer
lung cancer marker
main cell types:
? ? ?epithelial cells: EPCAM, CDH1, KRT7, KRT19
? ? ?immune cells: PTPRC, CD68, KIT, JCHAIN, MS4A1
? ? stromal cells：PECAM1, VMF, ACTA2
epithelial cell types:
? ? ?alveolar type 1:??AGER,?PDPN
? ? ?alveolar type 2:?ABCA3,?SFTPB,?SFTPC
? ? ?Club cells:?SCGB1A1,?MUC5B
? ? ?Basal cells:?KRT5,?KRT17,?NGFR,?TRP63
? ? ?Ciliated cells:?FOXJ1,?TMEM190,?CAPS
? ? ?Neuroendocrine:?ASCL1,?CALCA,?CHGA
stromal cell types:?
? ? ?Endothelial cells:?VWF,?PECAM1
? ? ?Lymphatic endothelial cells:?CCL21,?PROX1
? ? ?Fibroblasts:?PDGFRA,?LUM
? ? ?Myofibroblasts:?PDGFRA,?LUM,?MYLK,?ACTA2,?PDGFRB
? ? ?Smooth muscle cells:?MYLK,?ACTA2,?PDGFRB,?MYH11
? ? ?Mesothelial cells:?UPK3B,?WT1
Immune cell types:
? ? ?Alveolar Macrophages:?CD68,?LYZ,?FABP4,?MARCO,?C1QA,?APOC1
? ? ?Monocyte-derived macrophages:?CD69,?LYZ,?LGMN,?CSF1R,?CD14
? ? ?Monocytes:?LYZ,?S100A12,?FCN1,?S100A9,?CD14
? ? ?Myeloid dendritic cells:?CD1C,?FCER1A,?CLEC9A
? ? ?Plasmacytoid dendritic cells:?LILRA4,?IL3RA,?CLEC4C,?JCHAIN
? ? ?Mast cells:?KIT,?GATA2,?CPA3
? ? ?Conventional T cells:?CD3E,?IL7R,?CD40LG
? ? ?Regulatory T cells:?CD3E,?FOXP3,?CD40LG
? ? ?CD8+ T cells:?CD3E,?CD8A,?CCL5
? ? ?NK cells:?NKG7,?KLRD1,?KLRB1,?NCR1
? ? ?B cells:?MS4A1,?CD79A,?CD19
? ? ?Plasma cells:?JCHAIN,?IGKC,?IGHG1
ref.:?Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma
cell marker
immune cells:
? ? ?T cells:?CD2,?CD3D/E/G
? ? ? ? ? CD8+ T cells:?CD8A
? ? ? ? ? CD4+ T cells:?CD4
? ? ? ? ? CD8+ effector T:?GNLY,?GZMA,?GZMB,?GZMK
? ? ? ? ? Na?ve T cells:?CCR7,?LEF1,?IL7R,?SELL
? ? ? ? ? Exhausted T cells:?LAG3,?TIGIT,?
? ? ? ? ? Regulator T cells:?FOXP3,?IL2RA,?IKZF2
? ? ? ? ? Exhausted T cells, Regulator T cells:?CTLA4
? ? ? ? ? Tissue-resident memory T cells:?ITGAE,?ITGA1,?ZNF683
????B cells:?CD79A/B
????????Follicular B cells:?MS4A1,?HLA-DRs,?CXCR4
????Plasma cells:?MZB1,?JCHAIN
????Myeloid cells:?LYZ
????Neutrophils:?CSF3R,?S100A8/9,?FCGR3B
????Conventional type 1 dendritic cell (cDC1):?XCR1,?CLEC9A
????Conventional type 2 dendritic cell (cDC2):?FCER1A,?CD1C
????Mature dendritic cells:?LAMP3
????Follicular dendritic cells:?FDCSP
????Plasmacytoid dendritic cells:?IL3RA,?LILRA4,?CLEC4C
????Macrophages:?CD68
????M2 macrophages/Alternatively activated macrophages:?MRC1,?CD163
????Monocytes:?CD14,?FCN1
????Mast cells:?TPSAB1,?TPSB2,?GATA2
vessel cells:
????Endothelial cells：CLDN5, PECAM1,?VWF
????Tip cells:?DLL4,?KCNE3,?ESM1,?ANGPT2
????Vein endothelial cells:?ACKR1,?GJA5
????Lymphatic endothelial cells:?PROX1,?PDPN
????Pericytes:?RGS5,?CSPG4
stroma cells:
? ??Fibroblasts:?DCN,?COL1A1/2
? ??Myofibroblasts:?ACTA2,?MYH11
epiphelial cells:
? ??Epithelial cells:?CAPS,?SNTN
? ??Alveolar cells:?CLDN18,?AQP4
? ??Alveolar type 1 cells:?CAV1,?AGER
? ??Alveolar type 2 cells:?SFTPC,?SFTPA1,?ABCA3
? ??Club cells:?SCGB1A1,?SCGB3A1
? ??Basal cells:?KRT5,?KRT6A,?KRT14
????Ciliated cells:?FOXJ1,?TPPP3,?PIFO
