文獻(xiàn)DOI：10.1016/j.ejphar.2019.01.001

文獻(xiàn)PMID：30633888

文獻(xiàn)原文鏈接：http://doi.org.sci-hub.tw/10.1016/j.ejphar.2019.01.001

Does alpha-lipoic acid affect lipid profile? A meta-analysis and systematic review on randomized controlled trials.

α-硫辛酸會(huì)影響脂質(zhì)譜分布嗎？ 隨機(jī)對(duì)照試驗(yàn)的薈萃分析和系統(tǒng)評(píng)價(jià)

【Abstract】

Randomized controlled trials (RCTs) have demonstrated that alpha lipoic acid (ALA) may change lipid profile, but their results are contradictory. The aim of this study is to conduct a meta-analysis to assess the effects of ALA on lipid profile. Electronic database including ISI web of science, Ovid, PubMed/Medline, SCOPUS, and Google Scholar were searched up to February 2018. RCTs which assessed ALA effects on lipid profile were selected. Weighted mean difference (WMD) and 95% confidence intervals (CIs) in serum lipids concentrations were defined as intervention effects. Random effects model was used to estimate the pooled effect. Heterogeneity was measured by using I2 test. The protocol was registered with PROSPERO (No. CRD42017072365). Database search retrieved 12 articles. Serum total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-) levels were significantly lower in subjects supplemented with alpha-lipoic acid compared with controls (WMD=-10.18 mg/dL; 95% CI: -16.16, -4.20 mg/dL; P=0.001 and WMD=-9.22 mg/dL; 95% CI: -18.28, -0.16 mg/dL; P=0.001, respectively), but no significant changes were found for high density lipoprotein-cholesterol (HDL-c) (WMD: 3.02 mg/dL; 95% CI: -0.39, 6.43; P=0.082). The overall effect of ALA on serum triglyceride did not reveal any significant change, but in subgroup analysis based on health status (diabetic vs. non-diabetic), ALA decreased serum triglyceride levels in both diabetic and non-diabetic groups compared with controls. This meta-analysis revealed that ALA might favorably affect lipid profile especially LDL and TC. However, for confirming these results, more studies particularly among hyperlipidemic patients are needed.

Keywords: alpha lipoic acid, lipoprotein, lipids, cholesterol, triglyceride, meta-analysis

摘要翻譯：

隨機(jī)對(duì)照試驗(yàn)（RCTs）已經(jīng)證明α硫辛酸（ALA）可能改變脂質(zhì)譜，但這些研究結(jié)果是有矛盾的。本研究的目的是進(jìn)行薈萃分析，以評(píng)估ALA對(duì)脂質(zhì)譜的影響。搜索包括ISI科學(xué)網(wǎng)、Ovid、PubMed / Medline、SCOPUS和Google Scholar在內(nèi)的電子數(shù)據(jù)庫（至2018年2月）。選擇評(píng)估ALA對(duì)脂質(zhì)譜的影響的RCT。將血清脂質(zhì)濃度的加權(quán)平均差（WMD）和95％置信區(qū)間（CI）定義為干預(yù)效應(yīng)。隨機(jī)效應(yīng)模型用于估計(jì)匯總效應(yīng)。通過使用I2測試來測量異質(zhì)性。該協(xié)議已在PROSPERO（編號(hào)CRD42017072365）注冊。數(shù)據(jù)庫搜索檢索了12篇文章與對(duì)照組相比，補(bǔ)充α-硫辛酸的受試者的血清總膽固醇（TC）和低密度脂蛋白膽固醇（LDL-）水平顯著降低（WMD = -10.18 mg / dL; 95％CI：-16.16，-4.20 mg / dL; P = 0.001和WMD = -9.22 mg / dL; 95％CI：-18.28，-0.16 mg / dL; P = 0.001，但高密度脂蛋白膽固醇（HDL-）未發(fā)現(xiàn)顯著變化）（WMD：3.02mg / dL; 95％CI：-0.39,6.43; P = 0.082）。 ALA對(duì)血清甘油三酯的總體影響未顯示任何顯著變化，但在基于健康狀況（糖尿病與非糖尿?。┑膩喗M分析中，與對(duì)照相比，ALA降低糖尿病組和非糖尿病組中的血清甘油三酯水平。該薈萃分析顯示ALA可能有利地影響脂質(zhì)特征，尤其是LDL和TC。然而，為了證實(shí)這些結(jié)果，需要更多的研究，尤其是高脂血癥患者。

關(guān)鍵詞：α硫辛酸，脂蛋白，脂類，膽固醇，甘油三酯，薈萃分析