21-04-01
Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer.
PMID: 33557837
推薦理由：
1.基因：選取4種RNA編輯類型的“writers”，共計(jì)26個(gè)基因進(jìn)行分析，切入點(diǎn)好
2.基因周邊：mRNA、CNV、突變、相關(guān)性分析和預(yù)后
3.分子分型：8個(gè)GEO數(shù)據(jù)整合分析，sva::ComBat矯正批次效應(yīng)
4.分子分型周邊：GSVA、Ciborsort免疫浸潤
5.分型差異基因→構(gòu)建模型
6. 模型周邊：GSVA通路富集分析、差異miRNA、差異PDUI、差異A-I頻率
7.藥敏分析+免疫治療反應(yīng)
Immune landscape and a novel immunotherapy-related gene signature associated with clinical outcome in early-stage lung adenocarcinoma
PMID:32333046
推薦理由：ssGSEA計(jì)算免疫細(xì)胞浸潤→3個(gè)亞型→亞型差異分析→模型構(gòu)建
An Inflammatory Response-Related Gene Signature Can Impact the Immune Status and Predict the Prognosis of Hepatocellular Carcinoma
DOI:https://doi.org/10.3389/fonc.2021.644416
推薦理由：選取Inflammatory Response相關(guān)的200個(gè)基因作為切入點(diǎn)。類似的有ferroptosis，immune，energy metabolism, EMT，m6A，hypoxia
炎癥相關(guān)ncRNA數(shù)據(jù)庫：ncRI
21-03-30
Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment
PMID: 33627136
推薦理由：泛癌+糖酵解+lncRNA，任意拆開就是一篇SCI!
21-03-26
Novel Gene Signatures Predictive of Patient Recurrence-Free Survival and Castration Resistance in Prostate Cancer
PMID:33671634
推薦理由：
- 選取4個(gè)GEO數(shù)據(jù)集，以|logFC|>0.5& pvalue<0.05為界篩選差異基因，利用RRA方法得到287個(gè)差異基因。
2. 相當(dāng)全面整理了前列腺癌的數(shù)據(jù)集，如Belfast、MSKCC、CPC-GENE、Cambridge、Stockholm和相當(dāng)多的GEO數(shù)據(jù)集，如果是研究前列腺癌的，非常值得精讀！
常規(guī)的unicox→Lasso→逐步回歸，加上logistic回歸!
4.勇敢的與其他模型的ROC進(jìn)行對比！
RRA差異分析
整體路線圖
m 6 A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer
PMID: 32863943
推薦理由：根據(jù)與27個(gè)m6A相關(guān)的蛋白分析，結(jié)合CNV，甲基化，SNP數(shù)據(jù)，篩選出PI3K/AKT/mTOR通路，這思路也是絕了！
21-03-24
PMID: 32655701
推薦理由：ssGSEA計(jì)算Cancer Hallmark signature通路的評分，用Cox回歸計(jì)算每條通路的預(yù)后價(jià)值。不一樣的缺氧預(yù)后！
21-03-23
Pan-cancer analysis of the developmental pathways reveals non-canonical wnt signaling as a driver of mesenchymal-type tumors
PMID:32522670
推薦理由：系統(tǒng)的比較了癌癥和胚胎發(fā)育過程中，各自通路激活的情況，并篩選出關(guān)鍵EMT基因FZD2。
Characterization of an endoplasmic reticulum stress-related signature to evaluate immune features and predict prognosis in glioma IF:4.48分
PMID:33611848
推薦理由：從GeneCards收集內(nèi)質(zhì)網(wǎng)應(yīng)激相關(guān)基因（Endoplasmic Reticulum, ER），建立預(yù)后模型，這思路真清新！
相關(guān)綜述：
Endoplasmic Reticulum Stress and the Hallmarks of Cancer
Immunogenomic Gene Signature of Cell-Death Associated Genes with Prognostic Implications in Lung Cancer IF:6.126分
PMID：33466402
推薦理由：程序性細(xì)胞死亡（自噬、凋亡）和非程序性死亡（壞死）相關(guān)基因+免疫周邊，夠清新脫俗！
