The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. The pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through a process called transcription. There are three key parts of JAK-STAT signalling: Janus kinases (JAKs), signal transducer and activator of transcription proteins (STATs), and receptors (which bind the chemical signals).Disrupted JAK-STAT signalling may lead to a variety of diseases, such as skin conditions, cancers, and disorders affecting the immune system. Currently, several JAK-targeting drugs have been used in the clinic for treating diseases including rheumatoid arthritis and myeloproliferative.

STAT：?https://www.tsbiochem.com/target/STAT

EGFR;?https://www.tsbiochem.com/target/EGFR

HER:?https://www.tsbiochem.com/target/HER

Pim:?https://www.tsbiochem.com/target/Pim

JAK:?https://www.tsbiochem.com/target/JAK