"目錄號: HY-15341

Apoptosis-

BAM 7是Bax活化劑，EC50為3.3 μM。

Bcl-2 Family

相關(guān)產(chǎn)品

ABT-199-Navitoclax-ABT-737-WEHI-539 hydrochloride-A-1210477-A-1155463-Bax inhibitor peptide V5-Obatoclax-HA14-1-Marinopyrrole A-A-1331852-Gambogic Acid-UMI-77-AT-101 acetic acid-Pyridoclax-

生物活性

Description

BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.IC50 Value: 3.3 uM(EC50) [1]Target: Bcl-2 Familyin vitro: BAM7 emerged as the most effective competitor, achieving an IC50 of 3.3 μM, which compared favorably with the IC50 of unlabeled BIM SAHB, considering that the molecule is only one-sixth the size of the BIM BH3 α-helical peptide. Co-incubation of BAM7 (10 μM, 20 μM, 30 μM and 40 μM) and monomeric BAX (5μM) induced dose- and time-responsive BAX oligomerization in solution, The combinations of BAX with ANA-BAM16 and BAXK21E with BAM7 had comparatively little to no effect even at the 1:8 dose ratio [1].in vivo: N/AClinical trial: N/A

References

[1].Gavathiotis E, Reyna DE, Bellairs JA, Direct and selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012 Jul;8(7):639-45.