序列(三字母)：

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH

序列(單字母)：

DRVYIHPFH

分子式:

C56H78N16O13

分子量:

1183.34

CAS#:

34273-12-6

合成方法：

Synthetic

存儲(chǔ)條件：

-20 °C，避光，干燥

應(yīng)用：

Cardiovascular System & Diseases

產(chǎn)品描述：

Angiotensin I (1-9)在體內(nèi)被發(fā)現(xiàn)，在ACE抑制劑處理過的動(dòng)物體內(nèi)聚集。研究顯示，angiotensin I (1-9)可能是在內(nèi)皮細(xì)胞-關(guān)聯(lián)的ACE2的作用下由心臟和腎臟產(chǎn)生。Kramkowski等人發(fā)現(xiàn)在血小板中從Ang I產(chǎn)生的angiotensin I (1-9)能夠增強(qiáng)老鼠血栓的形成。

參考文獻(xiàn):

1.?Differential regulation of angiotensin peptide levels in plasma and kidney of the rat.?Campbell, DJ; et al., Hypertension, 18, 763, (1991);

2.?Differential Regulation of Angiotensin Peptides in Plasma and Kidney: Effects of Adrenalectomy and Estrogen Treatment.?Campbell, DJ; et al., Clin. Exp. Hypertens., 19, 687, (1997);

3.?A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9.?Donoghue, M; et al., Circ. Res., 87, E1, (2000).

4.?Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction?Fattah, C, et al., J. Am. Coll. Cardiol., 68, 2652, (2016);

5.?Angiotensin-(1-9) ameliorates pulmonary arterial hypertension via angiotensin type II receptor?Cha, SA, et al., Korean J. Physiol. Pharnacol., 22, 447, (2018).